[Beef]

I assume they are running this out of the shotgun correct?

I think it depends a lot on the QB. If you have a guy that has speed and can through then I would probably have to go with a dime formation with 6 DBs so you can get some speed out there. If they use a Tight End then you could probably switch to nickel and bring in another LB to cover him. You are going to have to mix up coverage a lot using 'spy' with safeties in man coverage, zones, some cover 2/3 if the situation will be a passing one. As you said, this is probably one of the hardest formations to defend against, especially when ran correctly with some decent players.

But I'll just keep with you will need a lot of speed out there on the defense to cover all of the skill guys -- 3/4 recievers, 0/1 Tight End, RB, and QB.